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目的:观察曲美他嗪对老年高血压伴左室肥厚患者左室舒张功能的改善作用。方法:选择老年高血压伴左室肥厚患者132例,随机分为2组:治疗组,给予口服曲美他嗪20mg,每日3次;对照组给予安慰剂,每日3次;2组疗程均为1个月。以彩色多普勒超声心动图观察2组治疗前后心脏结构和舒张功能的改变情况。结果:2组治疗前后室间隔舒张末期厚度、左室后壁舒张末期厚度均无明显改变。治疗组E峰与A峰比值较治疗前明显升高(P<0.05)。结论:曲美他嗪能在不逆转高血压患者左室肥厚的情况下,明显改善左室舒张功能。
Objective: To observe the effect of trimetazidine on left ventricular diastolic function in elderly hypertensive patients with left ventricular hypertrophy. Methods: Thirty-two elderly hypertensive patients with left ventricular hypertrophy were selected and randomly divided into two groups: treatment group, oral trimetazidine 20mg three times daily, control group placebo three times a day, All for 1 month. Color Doppler echocardiography was used to observe the change of cardiac structure and diastolic function in two groups before and after treatment. Results: Before and after treatment, there was no significant change in the thickness of the end-diastole and the end-diastolic thickness of the posterior wall of the two groups. The ratio of peak E to peak A in treatment group was significantly higher than that before treatment (P <0.05). Conclusion: Trimetazidine can significantly improve left ventricular diastolic function without reversing left ventricular hypertrophy in hypertensive patients.