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对178例不同年龄组的健康人群按0、1、6个月三次接种乙肝疫苗后,采血用ELISA法检测血清抗-HBs,对抗-HBs阴性者追加第四针乙肝疫苗后重新采血化验。结果表明:三针接种后仅0～9岁组与30～45岁组间抗-HBs阳性有非常显著性差异(X~2=7.18,P<0.01)。四针接种后与三针相比,除0～9岁组无显著性差异(P>0.05)外,10～19岁组(X~2=8.44,P<0.01)、20～29岁组(X~2=5.57,P<0.05)、30～45岁组(X~2=4.95,P<0.05)均有(非常)显著性差异。提示乙肝疫苗接种后及时采血化验血清抗-HBs很有必要,对抗-HBs阴性者给予追加接种乙肝疫苗,有望获得对乙肝的免疫力。为了提高免疫效果,同时还须参考有关学者对剂量与方法的改进措施。
178 healthy subjects of different age groups were vaccinated with hepatitis B vaccine three times at 0, 1 and 6 months after receiving hepatitis B vaccine. Serum anti-HBs were detected by ELISA and anti-HBs were re-collected after the fourth dose of hepatitis B vaccine. The results showed that there was a significant difference (-0.28 = 7.18, P <0.01) in anti-HBs positive in the 0-9 years old group and 30-45 years old group after three inoculation. Four-needle inoculation compared with the three-pin, except for 0 to 9 years old group no significant difference (P> 0.05), 10 to 19 years old group (X ~ 2 = 8.44, P <0.01) X ~ 2 = 5.57, P <0.05). There was significant difference between the age group of 30-45 (X ~ 2 = 4.95, P <0.05) Prompt hepatitis B vaccination prompt blood test serum anti-HBs after vaccination is necessary, anti-HBs were given additional vaccination of hepatitis B vaccine is expected to obtain immunity to hepatitis B. In order to improve the immune effect, we must also refer to the scholars for dose and method improvement measures.