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用３８只大耳白兔随机分成５组。Ⅰ组：正常对照组；Ⅱ组：单纯缺血组；Ⅲ组：缺血再灌注６０ｍｉｎ组；Ⅳ组：甘露醇合剂治疗组；Ⅴ组：盐水治疗对照组。结果：Ⅳ组肺组织丙二醛含量无明显增高，与Ⅱ组、Ⅲ组及Ⅴ组相比相差非常显著（Ｐ＜０．０１）。血气分析、ＷＢＣ计数、ＷＢＣ粘附率、肺组织Ｄ／Ｗ重比等指标，Ⅳ组与Ⅲ组及Ⅴ组相比均有显著差异（Ｐ＜０．０５～０．０１）。Ⅳ组肺组织学仅见微血管轻度充血、少量ＰＭＮ聚集。实验结果揭示：甘露醇、抗坏血酸对下肢缺血－再灌注后所致急性肺损伤有较好的防治作用。
38 rabbits were randomly divided into 5 groups. Group Ⅰ: Normal control group; Group Ⅱ: Ischemia group; Group Ⅲ: Ischemia reperfusion 60min group; Group Ⅳ: Mannitol mixture; GroupⅤ: saline control group. Results: The content of malondialdehyde in lung tissue of group Ⅳ was not significantly higher than that of group Ⅱ, Ⅲ and Ⅴ (P <0.01). Blood gas analysis, WBC count, WBC adhesion rate, D / W ratio of lung tissue and other indicators, Ⅳ and Ⅲ group and Ⅴ group were significantly different (P <0.05 ~ 0.01). The lung histology in group Ⅳ only showed slight hyperemia of microvascular and a small amount of PMN accumulation. The experimental results revealed that mannitol and ascorbic acid have a good preventive and therapeutic effect on acute lung injury induced by ischemia / reperfusion of the lower extremities.