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目的探讨急性脑梗死患者治疗前后血浆同型半胱氨酸(Hcy)水平的变化及意义。方法应用荧光偏振免疫分析法检测80例急性脑梗死患者治疗前后及40例正常人的血浆同型半胱氨酸水平,并对比分析。结果急性脑梗死患者治疗前的血浆同型半胱氨酸水平显著高于对照组(P<0.01),差异具有统计学意义。而且Hcy水平与梗死灶面积呈正相关(P<0.05)。急性脑梗死患者治疗后血浆同型半胱氨酸水平与治疗前比较,显著下降(P<0.01),差异具有统计学意义。结论高同型半胱氨酸血症与急性脑梗死的发生有关,血浆同型半胱氨酸水平可以作为急性脑梗死的诊断和疗效观察的辅助指标。
Objective To investigate the changes and significance of plasma homocysteine (Hcy) levels in patients with acute cerebral infarction before and after treatment. Methods Fluorescence polarization immunoassay was used to detect plasma homocysteine levels in 80 patients with acute cerebral infarction before and after treatment and 40 normal controls. Results The level of plasma homocysteine in patients with acute cerebral infarction before treatment was significantly higher than that in the control group (P <0.01). The difference was statistically significant. Moreover, the level of Hcy was positively correlated with infarct size (P <0.05). Plasma homocysteine levels in patients with acute cerebral infarction were significantly lower than those before treatment (P <0.01), and the difference was statistically significant. Conclusions Hyperhomocysteinemia is associated with the occurrence of acute cerebral infarction. Plasma homocysteine level can be used as an auxiliary indicator in the diagnosis and treatment of acute cerebral infarction.