论文部分内容阅读
经皮冠状动脉介入治疗是目前治疗冠心病的主要手段,但支架内再狭窄严重影响了其长期疗效。研究发现,支架内再狭窄的发生主要与内皮损伤、再内皮化延迟有关。快速完全的再内皮化是预防支架内再狭窄的重要方法。而内皮祖细胞在受损内皮再修复的过程中起重要作用,有研究发现通过促进内皮祖细胞动员、移植内皮祖细胞或者捕获循环中的内皮祖细胞等方式,促进其增殖、迁移、分化及归巢,可以加速受损血管的再内皮化,这为有效防止支架内再狭窄提供了一个很好的研究方向。
Percutaneous coronary intervention is the main treatment of coronary heart disease, but in-stent restenosis seriously affect its long-term efficacy. The study found that in-stent restenosis is mainly associated with endothelial injury and re-endothelialization delay. Rapid and complete re-endothelialization is an important method to prevent in-stent restenosis. However, endothelial progenitor cells play an important role in the process of re-repair of damaged endothelium. Some studies have found that it promotes the proliferation, migration, differentiation and differentiation of endothelial progenitor cells by promoting the mobilization of endothelial progenitor cells, transplanting endothelial progenitor cells or capturing circulating endothelial progenitor cells Homing, can accelerate the re-endothelialization of damaged blood vessels, which provides a good research direction for the effective prevention of in-stent restenosis.