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目的 探讨放疗前食管X片凶险征是否为独立预后因子及有该征者治疗失败表型.方法 104例患者入组,其中放疗前X片有凶险征者28例,无者76例,病人均采用单纯放疗.结果 有X片凶险征者3年生存率14%,3年局控率为25%显著低于无X片凶险征者的40%,41%(P值分别0.006,0.032);而远处转移率为27%显著高于无者的18%(P=0.048).经Cox多因素分析,有X片凶险征在生存,局控及远处转移等三项指标中均有统计学差异,P值分别为0.004,0.01及0.01.结论X片凶险征为提示中胸段食管癌预后的独立因子.有X片凶险征者治疗失败不仅在局部复发而且有全身转移.
Objective To investigate whether the risk of esophageal X-ray before radiotherapy is an independent prognostic factor and the treatment failure phenotype. Methods 104 patients were enrolled in the study. Among them, there were 28 patients with X-rays before radiotherapy and 76 patients without them. With simple radiotherapy, the 3-year survival rate of the X-ray danger was 14%, and the 3-year control rate was 25%, which was significantly lower than that of the 40% and 41% of the X-ray-dangerous persons (P = 0.006, 0.032). The distant metastasis rate was significantly higher in 27% than in those without (P=0.048). By Cox multivariate analysis, there were X-ray signs of survival, regional control, and distant metastasis. Differences in learning, P values were 0.004, 0.01, and 0.01. Conclusion The X-ray risk signs are independent factors that indicate the prognosis of the middle thoracic esophageal cancer. X-dangerous persons have failed in treatment not only in local recurrence but also in systemic metastasis.