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近年发现隐性自身免疫病是非生理性自身免疫反应,观察各种异常妊娠的病程,特别指出自身抗体中的抗磷脂抗体起重要作用,并将其阳性者表现出的动静脉血栓症、习惯性流产(反复流产、死产)等症状称为抗磷脂抗体综合征。Gleicher指出抗磷脂抗体参与生殖全过程,提议将抗磷脂抗体阳性者在生殖过程中表现的一系列症状称为生殖关联自身免疫异常综合征(RAFS)。 Conley等(1952)首先报道与抗磷脂抗体关系密切的狼疮抗凝血素(LAC)。在系统性红斑狼疮(SLE)患者血中有循环型抗凝血素可导致出血倾向,但SLE患者相反却有血栓形成倾向强。Bowie
In recent years, found that recessive autoimmune disease is non-physiological autoimmune response, observe the course of various abnormal pregnancy, in particular, pointed out that anti-phospholipid antibodies in autoantibodies play an important role, and its positive showed arteriovenous thrombosis, habitual Abortion (recurrent miscarriage, stillbirth) and other symptoms known as antiphospholipid antibody syndrome. Gleicher pointed out that anti-phospholipid antibodies are involved in the whole process of reproduction and proposed that a series of symptoms of anti-phospholipid antibody positive patients during reproduction are called reproductive-associated autoimmune syndrome (RAFS). Conley et al. (1952) first reported lupus anticoagulant (LAC) which is closely related to antiphospholipid antibodies. Cyclic anticoagulants can cause bleeding in patients with systemic lupus erythematosus (SLE), but patients with SLE, on the contrary, have a strong tendency to thrombosis. Bowie