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目的观察孕期缺铁性贫血(IDA)妇女及其新生儿免疫球蛋白和补体C3的变化。方法对33例IDA孕妇和32名正常孕妇及其新生儿及30名非孕妇女进行免疫指标检测,分析IDA孕妇免疫指标的变化及对新生儿各指标的影响。结果IDA孕妇IgG显著低于正常孕妇(P<0.01),IgM显著高于正常孕妇(P<0.05);孕妇和新生儿血清IgG呈正相关;与正常孕妇新生儿比较,IDA孕妇其新生儿血清中的IgG较低而IgM和C3较高(P<0.01,P<0.01,P<0.05)。结论缺铁性贫血孕妇血清IgG含量改变对新生儿有一定影响,其影响机制有待进一步研究。
Objective To observe the changes of immunoglobulin and complement C3 in pregnant women with iron deficiency anemia (IDA) and their newborns. Methods 33 cases of IDA pregnant women and 32 normal pregnant women, their newborns and 30 non-pregnant women were tested for the immune parameters, and the changes of immune indicators in IDA pregnant women and their effects on the indexes of newborns were analyzed. Results The IgG of IDA pregnant women was significantly lower than that of normal pregnant women (P <0.01), and the IgM was significantly higher than that of normal pregnant women (P <0.05). There was a positive correlation between serum IgA and IgG of pregnant women and newborns. Compared with normal pregnant women, Lower IgG and higher IgM and C3 (P <0.01, P <0.01, P <0.05). Conclusion The change of serum IgG in pregnant women with iron deficiency anemia has certain influence on newborn infants, and its mechanism needs further study.