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目的：研究压宁定在嗜铬细胞瘤围术期的应用。方法：20例ASA3－4级病人随机分成两组，U组（男4人，女4人，年龄33-67岁）主要用压宁足及R组（男8人，女4人，年龄35－68岁）主要用酚妥拉明控制血压。U组负荷剂量为0．5mg/kg，之后以40μg·kg-1·min-1速度静注维持。R组负荷剂量为0．04mg/kg，之后以2μg·kg-1·min-1速度静注维持。结果：U组血流动学显示更加平稳，U组术中血压比R组低（P＜0．05），但R组术后血压比U组低，U组围术期心率平稳，但R组术中心率增快，R组CVP比U组较早地升得更高，这限制了R组的输液速度。U组辅助用药比R组少（P＜0．05）。围术期应用压宁足未发现严重并发症。结论：压宁定用于嗜铬细胞瘤围术期降压有效且血流动力学平稳，辅助用药量少。
Objective: To study the application of fenidudine in the perioperative period of pheochromocytoma. METHODS: Twenty patients with ASA grade 3-4 were randomly divided into two groups. The U group (4 males and 4 females, aged 33-67 years) was mainly used to pressurize the feet and R group (8 males and 4 females, aged 35). -68 years old) Controls blood pressure mainly with phentolamine. The U group loading dose was 0.5 mg/kg, followed by intravenous infusion at a rate of 40 μg·kg-1·min-1. The loading dose in the R group was 0.04 mg/kg, and was then maintained intravenously at a rate of 2 μg·kg-1·min-1. RESULTS: Blood flow in the U group was more stable. Blood pressure in the U group was lower than that in the R group (P<0.05), but blood pressure was lower in the R group than in the U group, and heart rate was stable in the U group during the perioperative period, but in the R group. The surgical center rate was faster, and the CVP in the R group was higher than the U group earlier, which limited the infusion rate of the R group. U-assisted medication was less than R group (P<0.05). No severe complications were found during the perioperative period. Conclusion: The vasopressin is effective in the perioperative hypotension of pheochromocytoma and the hemodynamics is stable, and the adjuvant dose is less.