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目的:观察由雷贝拉唑联合阿莫西林、克拉霉素、替硝唑组成的10 d序贯疗法根除幽门螺杆菌(Hp)的疗效。方法:将经胃镜检查确诊为慢性活动性胃炎和胃十二指肠溃疡且Hp阳性的患者62例随机分为两组。治疗组方案为前5 d雷贝拉唑+阿莫西林,后5 d雷贝拉唑+克拉霉素+替硝唑;对照组治疗方案为雷贝拉唑+阿莫西林+克拉霉素,疗程10 d。结果:治疗组Hp根除率为90.3%,对照组Hp根除率为71.0%,两组间比较差异有统计学意义(P<0.05)。结论:以雷贝拉唑联合阿莫西林、克拉霉素、替硝唑组成的10 d序贯疗法根除Hp具有疗效高、耐受性好等优点。
Objective: To observe the efficacy of sequential therapy of rabeprazole combined with amoxicillin, clarithromycin and tinidazole in the eradication of Helicobacter pylori (Hp). Methods: Sixty-two patients with Hp positive chronic gastritis and gastroduodenal ulcer confirmed by endoscopy were randomly divided into two groups. The treatment group for the first 5 d rabeprazole + amoxicillin, after 5 d rabeprazole + clarithromycin + tinidazole; control group for the treatment of rabeprazole + amoxicillin + clarithromycin, Course of treatment 10 d. Results: The Hp eradication rate was 90.3% in the treatment group and 71.0% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion: The eradication of Hp with rabeprazole combined with amoxicillin, clarithromycin and tinidazole for 10 days has the advantages of high efficacy and good tolerability.