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在本研究中观察了一定剂量范围（２．５０×１０~（－４）～２．５×１０~（－７）ｍｏｌ／Ｌ）视黄酸（ｒｅｔｉｎｏｉｃａｃｉｄ．ＲＡ）对淋巴细胞膜上的转铁蛋白受体（ＣＤ７１）ｍＲＮＡ的影响。结果显示：大剂量ＲＡ（２．５×１０~（－４）ｍｏｌ／Ｌ）显著抑制ＣＤ７１ｍＲＮＡ产生，且这种抑制作用不能被加入的外源性人重组白介素２（ｒｈＩＬ－２）所逆转；２．５×１０~（－５）～２．５×１０~（－６）ｍｏｌ／ＬＲＡ则能增加ＣＤ７１ｍＲＮＡ含量，２．５×１０~（－７）ｍｏｌ／ＬＲＡ作用不明显（与二甲基亚砜（ＤＭＳＯ）溶剂对照比）。提示大剂量ＲＡ可能直接在基因转录水平上抑制了ＣＤ７１ＤＮＡ转录为ｍＲＮＡ。
In this study, we observed the effect of retinoic acid (RA) on the transfer of lymphocyte membrane in a dose range (2.50 × 10 -4 ~ 2.5 × 10 -7 mol / L) Protein receptor (CD71) mRNA. The results showed that high dose RA (2.5 × 10 -4 mol / L) significantly inhibited the production of CD71 mRNA, and this inhibition could not be reversed by the addition of exogenous human recombinant interleukin 2 (rhIL-2) 2.5 × 10 ~ (-5) ~ 2.5 × 10 ~ (-6) mol / LRA could increase the content of CD71 mRNA, and the effect of 2.5 × 10 ~ (-7) mol / LRA was not obvious Sulfoxide (DMSO) solvent control). These results suggest that high-dose RA may directly inhibit the transcription of CD71 DNA into mRNA at the level of gene transcription.