论文部分内容阅读
目的了解2型糖尿病(T2DM)患者合并非酒精性脂肪性肝病(NAFLD)患病率及相关危险因素。方法选取2013年1月—2015年2月住院T2DM患者137例为研究对象,采用临床对照研究,根据有无合并NAFLD分为观察组(T2DM合并NAFLD组)101例,对照组(单纯T2DM组)36例。观察二组患者的病史及既往病史、吸烟史、饮酒史、性别、年龄、血压、身高、体重、体重指数(BMI)、血糖、血脂、谷丙转氨酶、谷草转氨酶、肾功能及胰岛素抵抗指数(TYG)等指标,比较二组与代谢综合征及其各组分的相互关系。结果 1住院T2DM患者NAFLD检出率73.72%,男为82.67%、女为62.90%,性别有差异有统计学意义;2合并NAFLD组的BMI、甘油三酯、谷丙转氨酶、谷草转氨酶及TYG高于单纯T2DM,差异有统计学意义;多因素Logistic回归分析男性、BMI、空腹血糖及TYG是T2DM合并NAFLD的危险因素;3合并NAFLD组比较单纯T2DM组超重/肥胖及血脂紊乱差异有显著统计学意义,随着代谢因素增加,代谢综合征检出率成倍上升,二组间高血压病有明显的重叠性。结论重视T2DM与NAFLD共存不良结局,积极控制T2DM的体重指数、血糖及甘油三酯,减少NAFLD发生、发展。
Objective To investigate the prevalence and related risk factors of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM). Methods A total of 137 inpatients with T2DM from January 2013 to February 2015 were enrolled in this study. One hundred and eleven patients with T2DM and T2DM with NAFLD were enrolled in this study. The patients in control group (T2DM group) 36 cases. The patients’ history and past medical history, smoking history, drinking history, gender, age, blood pressure, height, weight, body mass index (BMI), blood glucose, blood lipid, alanine aminotransferase, aspartate aminotransferase, renal function and insulin resistance index TYG) and other indicators, the two groups compared with the metabolic syndrome and its components of the relationship. Results 1 Inpatient T2DM patients with NAFLD detection rate was 73.72%, male was 82.67%, female was 62.90%, the gender difference was statistically significant; 2 NAFLD group BMI, triglyceride, alanine aminotransferase, aspartate aminotransferase and TYG high Multivariate logistic regression analysis showed that male, BMI, fasting blood glucose and TYG were risk factors of T2DM complicated with NAFLD.3 Compared with NAFLD group, there was significant difference in overweight / obesity and dyslipidemia in T2DM alone group Significance, with the increase of metabolic factors, the detection rate of metabolic syndrome increased exponentially, there was a clear overlap between the two groups of hypertension. Conclusions It is important to pay attention to the coexistence of unfavorable outcome of T2DM and NAFLD, and to actively control the body mass index, blood glucose and triglycerides of T2DM and reduce the occurrence and development of NAFLD.