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目的:分析我院药品不良反应(ADR)发生的特点和一般规律,促进临床合理用药。方法:采用回顾性方法,对我院2008年全年上报的209份ADR报告,按患者年龄、性别、给药途径、引发ADR的药品种类、涉及器官或系统及临床表现等进行统计、分析。结果:静脉给药较其他途径更易发生ADR(占77.99%);抗感染药引发ADR的比例最高(66.99%),其次为中药制剂;头孢菌素类是引发ADR的主要抗感染药(59例,占42.14%),其中又以头孢匹胺为首。ADR的临床表现以皮疹、瘙痒等皮肤及附件损害为主,其次为消化系统及神经系统损害。结论:应强化ADR监测意识,完善相关报告分析制度,确保临床安全、有效、合理用药。
Objective: To analyze the characteristics and general rules of adverse drug reaction (ADR) in our hospital and to promote rational drug use in clinic. Methods: A retrospective analysis was conducted on 209 ADR reports reported in our hospital in 2008 according to patient’s age, sex, route of administration, type of drug causing ADR, organ or system and clinical manifestation. RESULTS: Intravenous administration was more likely to develop ADR than other routes (77.99%). Anti-infectives had the highest proportion of ADRs (66.99%), followed by traditional Chinese medicine preparations. Cephalosporins were the major anti-infectives for ADRs (59 , Accounting for 42.14%), which led to cephalosporins. The clinical manifestations of ADR to rash, itching and other skin and accessories damage, followed by digestive and nervous system damage. Conclusion: The awareness of ADR monitoring should be strengthened and the relevant reporting and analysis system should be improved to ensure clinical safety, effectiveness and rational use of drugs.