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对27例肝癌（HCC）、17例肝硬化及15例正常人外周血作了表型分析（CD3、CD4、CD8、CD16、CD25、CD56、Trδ）及肿瘤坏死因子（TNF）和IL－6检测，并按Child分级对HCC病人作了分级比较。结果表明：肝癌和肝硬化组外周血CD3、CD44／CD8比值均显著低于正常组（P＜0．05），HCCChildB级组T细胞下降比A组更显著；IL－6和TNF水平均高于正常组（P＜0．05）。初步认为：CD3、CD4阳性率下降及CD4／CD8比例倒置能较客观反应HCC免疫功能，细胞免疫功能水平与其肝功能状况直接相关。
Phenotypic analysis (CD3, CD4, CD8, CD16, CD25, CD56, Trδ) and tumor necrosis factor (TNF) and IL-6 were performed in 27 cases of hepatocellular carcinoma (HCC), 17 cases of cirrhosis, and 15 normal controls. Tests were performed and graded for HCC patients according to the Child grading. The results showed that the ratios of CD3 and CD44/CD8 in peripheral blood and hepatic cirrhosis group were significantly lower than those in normal group (P<0.05). The decline of T cells in HCCChild class B group was more significant than that in group A; the levels of IL-6 and TNF were higher In the normal group (P <0.05). It is initially believed that the decreased CD3 and CD4 positive rates and the inversion of CD4/CD8 ratio can directly reflect the immune function of HCC, and the level of cellular immune function is directly related to the status of liver function.