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角膜位于眼球最外侧,对眼球具有重要的保护作用,是主要屈光介质之一.外伤、炎症、营养不良、先天性疾病、肿瘤、角膜接触镜的使用,以及准分子激光角膜屈光手术的并发症都可能引起角膜损伤.目前,对于严重的角膜损伤仍没有十分理想的治疗方案.近年来,干细胞在该领域取得了许多研究进展,其中角膜上皮干细胞在角膜损伤修复过程中的作用毋庸置疑,但角膜基质干细胞和角膜内皮干细胞在该过程中的作用仍有争议.同时,应用其他来源干细胞诱导分化为角膜干细胞也给移植治疗带来了更多可能.现就干细胞在角膜上皮、基质和内皮损伤修复中的研究进展作一综述.“,”As the outermost part,cornea plays a critical role in protecting the eyeball and functions as main component of the dioptric media. Trauma,inflammation,malnutrition,inherited diseases,tumors,contact lens problems and complications of refractive surgeries may cause corneal injury. However,there are still no perfect treatments for severe corneal damage. Progresses have been made in the research field of corneal stem cells in recent years. Epithelial stem cells play an important role in corneal wound healing, whereas the contribution of stromal and endothelial stem cells is less studied. Moreover, corneal cells differentiated from alternative cell sources have a brilliant prospect in transplantation. This article reviewed the recent research progress of stem cells in the corneal epithelial,stromal and endothelial wound healing.