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国外基础研究认为钙拮抗剂异搏定可增加抗癌药长春新硷和阿霉素的细胞毒作用。根据该信息,本文用异搏定联合长春新硷、阿霉素组成“VOA”方案,对11例晚期癌症进行了第二期临床治疗研究,结果对晚期胃癌疗效最好,有效率达100％,其他癌也有较好的疗效,从而对晚期胃癌的临床治疗提供了一个较好的姑息性治疗方案。毒付作用不大,值得推广试用。同时在癌症临床治疗中采用钙拮抗剂配合化疗方面提供了一个先例。
According to basic research abroad, the calcium antagonist verapamil can increase the cytotoxic effects of the anticancer drugs Changchun Xinjing and doxorubicin. Based on this information, this article used verapamil in combination with Changchun Xinyi and Adriamycin to form a “VOA” protocol and conducted a second phase clinical study of 11 patients with advanced cancer. The results were the best for advanced gastric cancer, and the effective rate was 100%. Other cancers also have good curative effect, thus providing a good palliative treatment for the clinical treatment of advanced gastric cancer. The role of poison payment is not significant and it is worth promoting. It also provides a precedent for the use of calcium antagonists in combination with chemotherapy in the clinical treatment of cancer.