论文部分内容阅读
目的:探讨穴位贴敷联合益气活血方对奥沙利铂化疗所致神经毒性的影响。方法:将70例使用奥沙利铂的消化道恶性肿瘤患者随机分为两组各35例。两组均采用基础治疗,治疗组加用穴位敷贴联合益气活血方治疗,对照组配合甲钴胺片治疗。疗程均为6个化疗周期,观察两组治疗前后慢性神经毒性发生率、神经传导速度及不良反应。结果:治疗4、6个周期时,治疗组和对照组中Ⅰ~Ⅱ度神经毒性发生率分别为50.0%、76.7%和57.1%、88.4%,组间比较,差异均有统计学意义(P<0.05);治疗组治疗后正中神经及腓总神经传导速度与治疗前比较,差异均有统计学意义(P<0.05)。治疗组恶心、呕吐、贫血不良反应较对照组减轻(P<0.05)。结论:穴位贴敷联合益气活血方对预防奥沙利铂引起的慢性周围神经毒性有效,可降低其发生率,安全性高,且无严重不良反应发生。
Objective: To investigate the effect of acupoint sticking combined with invigorating Qi and activating blood on the neurotoxicity induced by oxaliplatin chemotherapy. Methods: Seventy patients with gastrointestinal malignancies treated with oxaliplatin were randomly divided into two groups of 35 cases each. The two groups were treated with basic treatment, the treatment group plus acupoint application of Yiqihuoxue Fang treatment, the control group with mecobalamin treatment. The course of treatment was 6 cycles of chemotherapy. The incidence of chronic neurotoxicity, nerve conduction velocity and adverse reactions were observed before and after treatment in both groups. Results: The neurotoxicity of Ⅰ ~ Ⅱ degree in treatment group and control group were 50.0%, 76.7%, 57.1% and 88.4% respectively at 4 and 6 cycles. The differences were statistically significant (P <0.05). The median nerve and common peroneal nerve conduction velocity in the treatment group after treatment were significantly different from those before treatment (P <0.05). The nausea, vomiting and adverse reactions of anemia in the treatment group were less than those in the control group (P <0.05). Conclusion: Acupoint Application combined with Nourishing Qi and Activating Blood Circulation is effective in preventing chronic peripheral neurotoxicity caused by oxaliplatin, which can reduce its incidence, high safety and no serious adverse reactions.