Icariin ameliorates learning and memory function via improving cerebral glucose metabolism disorder

• 作 者: ZHANG Ying YAN Fei CHEN Mei-xi
• 机 构: KeyLaboratoryofBasicPharmacologyofMinistryofEducationandJointInternationalResearchLaboratoryofEthnom
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2018年9期
• 关键词: ICARIIN ALZHEIMER disease glucosemetabolism glucose TRANSPORTER 1
• 基金项目: National Natural Science Foundation of China(81660599),Foundation of Zunyi Medical University (2013F-686,2013F-738),Postgraduate Education Foundation of Guizhou Province(KYJJ2017008).

OBJECTIVE To investigate the protective effect of icariin (ICA) on learning and memory function in APP/PS1/Tau triple transgenic Alzheimer disease mice (3 × Tg-AD mice), and then to explore whether its mechanism is related to the improvement of brain