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目的分析脑出血患者应用凝血功能检测对预后判断的价值。方法 88例脑出血患者,依据患者首次凝血功能检测结果分为观察组(46例)和对照组(42例)。采集所有患者在入院时、出血后12、24、48、72 h时的空腹手肘静脉血样,进行凝血功能检测,统计并比较两组的凝血指标变化以及病情转归情况。结果观察组出血后48、72 h检测得到的抗凝血酶Ⅲ(AT-Ⅲ)的下降幅度和D-二聚体(D-D)、内皮素-1(ET-1)以及血栓调节蛋白(TM)的上升幅度均大于对照组,差异有统计学意义(P<0.05);观察组好转16例、残疾18例、植物状态5例、死亡7例;对照组分别为36、5、1、0例。两组患者病情转归情况比较差异具有统计学意义(P<0.05)。结论凝血功能检测对于脑出血患者的预后判断有独特的临床价值。临床可以通过凝血功检测判断患者预后,凝血功能指标变化较大者可以采取相应治疗措施。
Objective To analyze the value of coagulation test in judging prognosis of patients with intracerebral hemorrhage. Methods 88 patients with cerebral hemorrhage were divided into observation group (46 cases) and control group (42 cases) according to the results of the first coagulation test. Fasting elbow venous blood samples were collected from all patients at admission, 12, 24, 48 and 72 h after hemorrhage, and the coagulation function was measured. The changes of coagulation indexes and the outcome of the two groups were compared and analyzed. Results The decrease of antithrombin III (AT-Ⅲ) and the decrease of D-dimer (DD), endothelin-1 (ET-1) and thrombomodulin (TM ) Increased more than the control group, the difference was statistically significant (P <0.05); the observation group improved in 16 cases, 18 cases of disability, plant status in 5 cases, 7 cases of death; control group were 36,5,1,0 example. There was significant difference between the two groups in the prognosis of patients (P <0.05). Conclusion The coagulation test has a unique clinical value for the prognosis of patients with intracerebral hemorrhage. Clinic can determine the prognosis of patients by coagulation test, coagulation function changes can take the appropriate treatment.