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目的探讨替诺福韦酯联合拉米夫定治疗艾滋病合并乙型肝炎病毒感染的临床疗效。方法选取攀枝花市第四人民医院2015年3月—2016年3月收治的艾滋病合并乙型肝炎病毒感染患者100例,随机分为对照组和观察组,每组50例。对照组患者给予拉米夫定单一用药治疗,观察组患者在对照组基础上给予替诺福韦酯治疗,两组患者均持续治疗8周。观察比较两组患者治疗24、48周丙氨酸氨基转移酶(ALT)复常率及HBV-DNA血清载量。结果治疗24、48周后,观察组患者ALT复常率高于对照组(P<0.05)。治疗前,两组患者HBV-DNA血清载量比较,差异无统计学意义(P>0.05);治疗后24、48周后,观察组患者HBV-DNA血清载量低于对照组(P<0.05)。结论替诺福韦酯联合拉米夫定治疗艾滋病合并乙型肝炎病毒感染的临床疗效较佳,可明显提高ALT复常率,降低HBV-DNA血清载量。
Objective To investigate the clinical efficacy of tenofovir dipivoxil combined with lamivudine in the treatment of AIDS with hepatitis B virus infection. Methods 100 cases of AIDS-infected patients with hepatitis B virus infection in the Fourth People’s Hospital of Panzhihua City from March 2015 to March 2016 were randomly divided into control group and observation group, 50 cases in each group. Patients in the control group received lamivudine monotherapy, and patients in the observation group received tenofovir dipivoxil on the basis of the control group. Both groups were treated for 8 weeks. The normalization rate of alanine aminotransferase (ALT) and serum HBV-DNA load of 24 and 48 weeks after treatment in both groups were observed and compared. Results After treatment for 24 and 48 weeks, the recovery rate of ALT in observation group was higher than that in control group (P <0.05). Serum HBV-DNA levels of two groups were not significantly different before treatment (P> 0.05). After 24 and 48 weeks of treatment, serum HBV-DNA levels in the observation group were lower than those in the control group (P <0.05) ). Conclusion Tenofovir disoproxil combined with lamivudine treatment of AIDS with hepatitis B virus infection with better clinical efficacy, can significantly improve the rate of ALT normalization and reduce HBV-DNA serum load.