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目的探讨无创正压通气(NIPPV)联合呼吸兴奋剂治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并轻中度肺性脑病的治疗效果。方法 60例AECOPD患者均分为对照组(仅用常规治疗,包括呼吸兴奋剂)和治疗组(加用NIPPV)。观察两组治疗前后的症状改善情况、动脉血气分析及48h后的治疗效果。结果治疗中及治疗结束时,治疗组血气分析、临床症状均比术前明显改善。治疗组的改善比对照组更为明显,总有效率高于对照组(90.0%vs.33.3%)(P<0.05)。结论NIPPV联合呼吸兴奋剂治疗AECOPD合并轻中度肺性脑病安全、有效。
Objective To investigate the therapeutic effect of noninvasive positive pressure ventilation (NIPPV) combined with respiratory stimulant in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with mild to moderate pulmonary encephalopathy. Methods Sixty patients with AECOPD were divided into control group (conventional therapy only, including respiratory stimulant) and treatment group (plus NIPPV). The symptoms of both groups were observed before and after treatment, arterial blood gas analysis and treatment after 48h. Results During treatment and at the end of treatment, blood gas analysis and clinical symptoms in the treatment group were significantly improved compared with that before operation. Treatment group improved more significantly than the control group, the total effective rate was higher than the control group (90.0% vs.33.3%) (P <0.05). Conclusion NIPPV combined with respiratory stimulant in the treatment of AECOPD with mild to moderate pulmonary encephalopathy is safe and effective.