Differentiation renders susceptibility to excitotoxicity in HT22 neurons

• 作 者: Minchao He Jun Liu Shaowu Chen
• 机 构: DepartmentofNeurology,LaboratoryforAlzheimer',sDisease&,AgingResearch,DepartmentofNeurology,Mo
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2013年14期
• 关键词: 海马神经元细胞 诱导分化 兴奋性 毒性 易感性 谷氨酸受体 D-天冬氨酸 MK-801 neural regeneration brain injury H
• 基金项目: supported by grants from the Medical Research and Development Service,Department of Veterans Affairs,and resources from the Midwest Biomedical Research Foundation,grants from the Alzheimer’s Associati

HT22 is an immortalized mouse hippocampal neuronal cell line that does not express cholinergic and glutamate receptors like mature hippocampal neurons in vivo.This in part prevents its use as a model for mature hippocampal neurons in memory-related studie