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探讨了海洋中常见药残磺胺嘧啶(SD)和磺胺甲恶唑(SMX)对球形棕囊藻和东海原甲藻生长的影响。结果表明:当这两种磺胺药物浓度大于20 mg/L时,球形棕囊藻和东海原甲藻的生长明显被抑制;SD和SMX对球形棕囊藻半数生长影响的浓度(EC50)分别为60～80 mg/L和20～40 mg/L;SD和SMX对东海原甲藻半数生长影响的浓度分别为20～40 mg/L和40～60 mg/L;两种藻培养96 h时扫描电镜观察,均显示高浓度下藻细胞膜严重破损,说明磺胺药物对其生长具有抑制作用。EC50对比表明球形棕囊藻对SD的耐受性强于SMX,而东海原甲藻对SMX的耐受性强于SD。两种藻对药残的耐受性明显强于其他藻种,在高浓度药残环境中占据生存优势。通过这项研究,试图探讨磺胺药物对河口及近海养殖区赤潮频发和赤潮消亡的影响。
The effects of the common drugs such as methamphetamine (SD) and sulfamethoxazole (SMX) on the growth of Phaeocystis globosa and Prorocentrum donghaiense were discussed. The results showed that when the concentrations of these two sulfonamides were more than 20 mg / L, the growth of Phaeocystis globosa and Prorocentrum donghaiense was significantly inhibited. The EC50 of SD and SMX on the growth of Phaeocystis globosides were 60 to 80 mg / L and 20 to 40 mg / L, respectively. The concentrations of SD and SMX on the growth of P. donghaiense were 20-40 mg / L and 40-60 mg / L, respectively. Scanning electron microscopy showed that the algae cell membrane under high concentrations of severe damage, indicating that sulfa drugs have an inhibitory effect on their growth. EC50 comparison showed that B. globosa was more tolerant to SD than SMX, while Prorocentrum donghaiense had stronger tolerance to SMX than SD. Both algae tolerance to drug residues was significantly stronger than other algae species, occupy the survival advantage in high concentrations of drug residues environment. Through this study, it is attempted to explore the impact of sulfa drugs on the frequent occurrence of red tides and the disappearance of red tides in estuarine and offshore culture areas.