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目的:探讨小剂量重组人生长激素(rhGH)联合左卡尼汀治疗透析营养不良的疗效。方法:选择住院透析营养不良患者91例,分小剂量组47例,透析后rhGH 3U/次,3次/1周,皮下注射,左卡尼汀,1g/次,静脉注射, 3次/1周;常规剂量组28例,rhGH 5U/次,其他同小剂量组;对照组16例不用rhGH和左卡尼汀;疗程3个月。观察3组治疗前后血浆总蛋白、白蛋白、血清转铁蛋白及前白蛋白浓度变化。结果:小剂量和常规剂量组治疗前后各项指标均有显著差异(p<0.05),两组与对照组治疗后比较,各项指标也均有显著差异(P<0.05),而小剂量与常规剂量组治疗后比较差异无统计学意义(P>0.05)。结论:左卡尼汀联合小剂量rhGH可有效改善透析并发营养不良患者的营养状况,且可节约医疗资源,减轻患者负担。
Objective: To investigate the effect of low dose recombinant human growth hormone (rhGH) combined with levocarnitine in the treatment of malnutrition. Methods: Ninety-one patients with malnourished in-hospital dialysis, 47 patients in low-dose group, rhGH 3U / time, 3 times / 1 week after dialysis were injected subcutaneously with levocarnitine, 1g / Week; conventional dose group 28 cases, rhGH 5U / times, the same with other small dose group; control group 16 cases without rhGH and levocarnitine; course of treatment for 3 months. The changes of plasma total protein, albumin, serum transferrin and prealbumin concentration before and after treatment were observed. Results: There was significant difference between the two groups before and after treatment (p <0.05), and there was significant difference (P <0.05) between the two groups and the control group after treatment There was no significant difference in the conventional dose group after treatment (P> 0.05). Conclusion: L-carnitine combined with low-dose rhGH can effectively improve the nutritional status of dialysis patients with malnutrition, and can save medical resources and reduce the burden on patients.