Transdifferentiation of pancreatic α-cells into insulinsecreting cells: From experimental models to

• 作 者: Jieli Lu Rami Jaafer Rémy
• 机 构: Sino-FrenchLifeScienceandGenomicCenter,ShanghaiClinicalCenterforEndocrineandMetabolicDiseases,Inserm
• 出 处: 世界糖尿病杂志：英文版（电子版）
• 发表日期: 2014年6期
• 关键词: ISLET GLUCAGON UNDERLYING metabolism regeneration reporting producing mature hom
• 基金项目: Supported by The Agence National de Recherche(ANR 2010 BLAN 1240 01),the Ligue contre le Cancer du Rh?ne and de la Loire,the CMIRA program of Region Rh?ne-Alpes,No.12004959-01,the Fondation ARC pour l

Pancreatic insulin-secreting β-cells are essential regulators of glucose metabolism. New strategies are cur-rently being investigated to create insulin-producing β cells to replace deficient β cells, including the differentiation of either stem or progeni