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青藤碱(Sinomenine,SIN)是从中药青风藤分离出的一种生物碱单体,分子式为C19H23NO4,结构类似于吗啡,具有镇痛镇静、镇咳局麻、降血压、抗炎等作用,为植物中很强的组织胺释放剂。青藤碱除具有镇静抗炎作用外,对肿瘤细胞增殖也有较强的抑制作用,能够抑制多种恶性肿瘤细胞的生长~([1])。现将青藤碱抗肿瘤作用研究进展作一综述。1青藤碱抗宫颈癌作用1.1青藤碱抑制宫颈癌细胞增殖张瑜等~([2])探讨了青藤碱对宫颈癌Hela细胞的抑制作用。结果表明0.1~2.5 mmol·L~(-1)青藤碱均能抑制宫颈癌Hela细胞增殖,并呈时间、剂量依赖性;青藤碱作用后,细胞
Sinomenine (SIN) is a kind of alkaloid monomer isolated from Chinese medicine Qingfengtu. Its molecular formula is C19H23NO4. Its structure is similar to that of morphine. It has the functions of analgesic and sedation, local antitussive, hypotensive and anti-inflammatory , A strong histamine release agent in plants. In addition to sedative anti-inflammatory effects of sinomenine, the proliferation of tumor cells also have a strong inhibitory effect, can inhibit the growth of a variety of malignant tumor ~ ([1]). The anti-tumor effects of sinomenine are reviewed. 1 sinomenine anti-cervical cancer effect of 1.1 sinomenine inhibition of cervical cancer cell proliferation Zhang Yu et al ~ ([2]) to explore sinomenine on cervical cancer Hela cells. The results showed that 0.1 ~ 2.5 mmol·L -1 sinomenine could inhibit the proliferation of cervical cancer Hela cells in a time-and dose-dependent manner. After sinomenine treatment,