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应用放射免疫分析法对４２例脑梗塞患者血浆β－ＥＰ、ＤｙｎＡ１－１３含量进行了测定。结果显示，脑梗塞急性期且梗塞灶体积大者血浆β－ＥＰ含量明显升高，ＤｙｎＡ１－１３含量显著降低（Ｐ＜０．０５）。脑梗塞病情程度越重，β－ＥＰ含量升高越明显，两者呈正相关（ｒ＝０．０５）。提示内源性阿片肽在缺血性脑梗塞中具有重要作用，β－ＥＰ促进了脑损伤缺血性脑水肿的形成和发展，而ＤｙｎＡ１－１３对其可能具有保护作用。
The plasma levels of β-EP and DynA1-13 in 42 patients with cerebral infarction were measured by radioimmunoassay. The results showed that in the acute stage of cerebral infarction, the plasma β-EP content was significantly increased and the content of DynA1-13 was significantly decreased (P <0.05). The more severity of cerebral infarction, the more obvious the increase of β-EP, the two were positively correlated (r = 0.05). It is suggested that endogenous opioid peptide plays an important role in ischemic cerebral infarction. Β-EP may promote the formation and development of ischemic cerebral edema in brain injury, and DynA1-13 may have protective effect on it.