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①目的观察急性心肌梗塞（ＡＭＩ）病人血清肌酸磷酸激酶（ＣＫ）及其亚型的变化，以探讨对ＡＭＩ早期诊断及病情变化的意义。②方法应用琼脂糖凝胶电泳法检测２０例ＡＭＩ病人血清ＣＫ总活力及其亚型ＭＭ变化，并与对照组和心绞痛组进行了比较。③结果ＡＭＩ发病３ｈ内，ＣＫ总活力和ＣＫ－ＭＢ与对照组和心绞痛组均无明显改变，而ＭＭ３及ＭＭ３／ＭＭ１比值则明显高于上述两组（ｔ＝７．８１，１０．０８，Ｐ均＜０．０１）。ＡＭＩ发病后，ＣＫ总活力和ＣＫ－ＭＢ达到峰值时间分别为２３．２和２１．６ｈ，而ＭＭ３／ＭＭ１则在１２．３ｈ达到峰值，ＭＭ３／ＭＭ１比值达峰值时间明显缩短（ｔ＝７．４５，Ｐ＜０．０１）。④结论检测ＣＫ及其亚型的变化有助于对ＡＭＩ的早期诊断和病情判断。
Objective To observe the changes of serum creatine phosphokinase (CK) and its subtypes in patients with acute myocardial infarction (AMI) so as to explore the significance of early diagnosis and changes of AMI. Methods The agarose gel electrophoresis was used to detect the changes of serum total CK and subtypes MM in 20 AMI patients and compared with the control group and angina pectoris group. ③ Results Within 3 hours after onset of AMI, CK activity and CK-MB did not change significantly in both groups and angina groups, but the ratios of MM3 and MM3 / MM1 were significantly higher than those of the above two groups (t = 7.81,10.08, P <0.01). After AMI onset, the total CK and MB-MB peaked at 23.2 and 21.6 h, respectively, whereas MM3 / MM1 peaked at 12.3 h and peaked at MM3 / MM1 (t = 7). 45, P <0.01). ④ Conclusion Detection of CK and its subtypes changes in the early diagnosis of AMI and disease judgment.