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为评价血清5′核苷酸磷酸二酯酶同工酶 V(5′NPD-V)和甲胎蛋白(AFP)联检对原发性肝癌(PHC)的诊断意义。本文分别采用聚丙烯酰胺电泳法和放射免疫法检测90例 PHC 和84例良性肝病患者血清5′NPD-V 和AFP 浓度(≤25ng/ml 为阴性)。结果显示 PHC 患者血清5′NPD-V 和 AFP 的阳性率分别为77.8%和76.7%,两者联合检测的阳性率为90%,显著高于任一单项阳性率(p<0.05),5′NPD-V 在 AFP 阴性或低浓度升高的 PHC 中阳性率为59.5%。从而提示5′NPD-V 有助于 AFP 阴性或低浓度升高 PHC 的诊断,两者联合检测显著提高 PHC 的检出率。
To evaluate the diagnostic value of serum 5’ nucleotide phosphodiesterase isoenzyme V (5’NPD-V) and alpha fetoprotein (AFP) in primary liver cancer (PHC). In this article, the concentrations of serum 5′NPD-V and AFP (≤25ng/ml were negative) in 90 patients with PHC and 84 patients with benign liver disease were detected by polyacrylamide electrophoresis and radioimmunoassay, respectively. The results showed that the positive rates of serum 5′NPD-V and AFP in PHC patients were 77.8% and 76.7% respectively, and the positive rate of the combined detection of both was 90%, which was significantly higher than that of any single positive rate (p<0.05). The positive rate of NPD-V in AFP-negative or low-increased PHC was 59.5%. This suggests that the 5′NPD-V is helpful in the diagnosis of AFP negative or low-level elevated PHC, and the combined detection of both can significantly increase the detection rate of PHC.