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某些工业化学物质的毒性作用涉及严重的肝损害,并且潜在的肝毒性物质不断地增加。血清丙氨酸转氨酶(S-ALAT)、天冬氨酸转氨酶(S一ASAT)及卜谷氨酸转肤酶(S一卜GT)等的测定已作为接触有机溶剂工人的肝损害筛选指标。在筛选时这些指标的异常率较低,可能是因为这些指标不敏感,不能检出肝损害。因此,有必要对其它较灵敏而特异的检验指标进行研究。血清胆汁酸浓度的测定在检出不严重的肝功能
The toxic effects of certain industrial chemicals involve severe liver damage, and the potential for hepatotoxic substances continues to increase. The determination of serum alanine aminotransferase (S-ALAT), aspartate aminotransferase (S-ASAT), and glutamaterine transaldolase (S-GT) has been used as an indicator of liver damage in workers exposed to organic solvents. The low rate of abnormality of these indicators at screening may be due to insensitivity of these indicators and failure to detect liver damage. Therefore, it is necessary to study other sensitive and specific test indicators. Determination of serum bile acid concentration in the detection of non-severe liver function