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目的调查武进区35~70岁人群高尿酸血症患病率及影响因素,为高尿酸血症的防治提供科学依据。方法采用随机整群抽样的方法,在常州市武进区抽取6个行政村(居委会)作为调查地区,以所有居住满4年的35~70岁居民作为调查对象,进行问卷调查、体格检查和生化指标检验,资料完整的研究对象共3 122人。结果研究人群高尿酸血症患病率为18.4%,其中男性患病率为26.8%,高于女性(11.9%),差异有统计学意义(P<0.01)。男性血尿酸水平为(373.17±109.56)μmol/L,高于女性[(292.23±99.03)μmol/L],差异有统计学意义(t=21.309,P<0.01)。高尿酸血症组男性所占比例、年龄、体质指数(BMI)、腰围、臀围、吸烟率、饮酒率、血肌酐、收缩压、舒张压、血尿酸、甘油三酯、总胆固醇、空腹血糖水平均高于血尿酸正常组,差异均有统计学意义(P<0.01)。高尿酸血症组高脂血症检出率最高(78.9%),其次为超重和肥胖(66.1%)、高甘油三酯(62.1%)、高血压(56.2%)、腹型肥胖(37.7%)和糖尿病(9.2%)。多因素非条件logistic回归分析显示,超重(OR=1.752,95%CI:1.372~2.239)、肥胖(OR=1.816,95%CI:1.242~2.655)、腹型肥胖(OR=1.767,95%CI:1.335~2.339)、高血压(OR=1.687,95%CI:1.358~2.096)、血脂异常(OR=2.523,95%CI:1.997~3.188)、血肌酐(OR=1.048,95%CI:1.039~1.058)、男性饮酒(OR=1.789,95%CI:1.362~2.351)和女性年龄(OR=1.029,95%CI:1.009~1.049)均为高尿酸血症的危险因素,而吸烟和糖尿病与高尿酸血症的关系未见统计学意义。结论超重、肥胖、腹型肥胖、高血压、血脂异常、血肌酐、男性饮酒和女性年龄均为高尿酸血症的危险因素。
Objective To investigate the prevalence and influencing factors of hyperuricemia among 35 ~ 70-year-olds in Wujin District and provide a scientific basis for the prevention and treatment of hyperuricemia. Methods A random cluster sampling method was used to select 6 administrative villages (neighborhood committees) in Wujin District of Changzhou as the survey area. All the residents aged 35-70 years who lived for 4 years were surveyed, physical examination and biochemistry Index test, a complete data set of 3 122 people. Results The prevalence of hyperuricemia in the study population was 18.4%, of which the prevalence was 26.8% in males and 11.3% in females, with a significant difference (P <0.01). The level of serum uric acid in male was (373.17 ± 109.56) μmol / L, higher than that in female [(292.23 ± 99.03) μmol / L], the difference was statistically significant (t = 21.309, P <0.01). The proportion of male patients with hyperuricemia, age, body mass index (BMI), waist circumference, hip circumference, smoking rate, drinking rate, serum creatinine, systolic blood pressure, diastolic blood pressure, blood uric acid, triglyceride, total cholesterol, fasting blood glucose The level of serum uric acid was higher than the normal group, the difference was statistically significant (P <0.01). Hyperuricemia had the highest incidence of hyperlipidemia (78.9%), followed by overweight and obesity (66.1%), high triglycerides (62.1%), hypertension (56.2%), abdominal obesity ) And diabetes (9.2%). Multivariate non-conditional logistic regression analysis showed that obesity (OR = 1.752, 95% CI: 1.372-2.239), obesity (OR = 1.816, 95% CI: 1.242-2.655) (OR = 1.687, 95% CI: 1.358-2.096), dyslipidemia (OR = 2.523, 95% CI: 1.997-3.188), serum creatinine (OR = 1.048, 95% CI: 1.039 ~ 1.058). Male alcohol consumption (OR = 1.789, 95% CI: 1.362-2.351) and female age (OR = 1.029, 95% CI: 1.009-1.049) were all risk factors for hyperuricemia. The relationship between hyperuricemia was not statistically significant. Conclusion Overweight, obesity, abdominal obesity, hypertension, dyslipidemia, serum creatinine, male alcohol intake and female age are the risk factors of hyperuricemia.