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某些与DNA修复缺陷有关的人类疾病,除了表现淋巴样肿瘤发病率增高外,还可出现免疫缺陷的证据。这表明免疫系统在未能维持其细胞DNA完整性的特殊情况下易受损伤。最近研究指出、免疫球蛋白基因的活化可导致DNA重排与体细胞突变。因此抗体的产生与DNA改变有关。本文试图阐明在某些免疫病的发病机理中,有关DNA损伤及其修复缺陷的作用。与DNA修复缺陷有关的疾病老化加速可能与DNA修复缺陷有关,而体细胞突变可能促进老化过程。免疫缺陷及自身免疫缺陷伴有老化。有人断定,在主要的组织相容性复合物
Some human diseases associated with defects in DNA repair may show evidence of immunodeficiency in addition to an increased incidence of lymphoid tumors. This shows that the immune system is vulnerable in the special case of failure to maintain the integrity of its cellular DNA. Recent studies indicate that activation of immunoglobulin genes can lead to DNA rearrangements and somatic mutations. Therefore, the production of antibodies and DNA changes. This article attempts to elucidate the role of DNA damage and repair defects in the pathogenesis of certain immunological diseases. Aging associated with DNA repair defects Aging may be related to DNA repair defects, while somatic mutations may promote aging. Immune deficiency and autoimmune deficiency associated with aging. It has been concluded that the major histocompatibility complex