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目的探讨血清心肌肌钙蛋白I(cTnI)在急性有机农药中毒(AOPP)患者心肌损伤早期检测意义及其对心脏事件发生率的检测意义。方法将50例AOPP患者分轻度(A组),中度(B组),重度(C组),在就诊4小时(h)内,第24h分别检测cTnI,肌酸激酶同工酶(CK-MB),心电图(ECG);比较cTnI和其他项目对三组AOPP患者心肌损伤早期检出率的差异性。结果C组cTnI明显高于A,B组,有显著性差异;B组亦高于A组;有显著性差异;各组CK-MB,ECG无显著性差异(P>0.05);cTnI升高的例数显著高于其他项目(P<0.05)。结论应用血清cTnI检测方法能提高AOPP患者早期心肌损伤的检出率,其灵敏度高于CK-MB和ECG检查,并能预测心脏事件的发生。
Objective To investigate the significance of serum cardiac troponin I (cTnI) detection in the early stage of myocardial injury in patients with acute organic pesticide poisoning (AOPP) and its significance in detecting the incidence of cardiac events. Methods Fifty patients with AOPP were divided into mild group (A group), moderate group (B group) and severe group (C group). The levels of cTnI and creatine kinase isoenzyme (CK) were detected at 4 hours -MB) and electrocardiogram (ECG). The differences in the early detection rate of myocardial injury among three groups of AOPP were compared between cTnI and other items. Results The cTnI of group C was significantly higher than that of group A and B (P <0.05). There was a significant difference between group C and group A (P <0.05). The cTnI of group C was significantly higher than that of group A The number of cases was significantly higher than other items (P <0.05). Conclusion The detection of early detection of myocardial damage in patients with AOPP using serum cTnI detection method is more sensitive than CK-MB and ECG, and can predict the occurrence of cardiac events.