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目的:了解永康市城乡妇女人乳头瘤病毒(HPV)感染状况以及HPV感染在人群中的分布情况。方法:2007年4月～2008年5月采用整群分层抽样法对永康市城镇10个社区和经济开发区10个村的已婚妇女进行宫颈癌筛查,在签署知情同意书后对入选对象进行流行病学问卷调查,同时采集受试者宫颈脱落细胞进行宫颈脱落细胞液基细胞学检测,采用PCR原位杂交法行HPV23个型别的检测。结果:共1 050名妇女入选,高危型HPV阳性检出率为24.9%,低危型HPV阳性检出率为9.2%。在高危型HPV阳性人群中,16、33和58型HPV百分比依次为53.3%、14.9%和14.6%,高危型HPV的年龄别人群检出率(25～34岁、35～44岁、45～59岁)依次为28.5%、20.0%、30.6%;低危型HPV的年龄别人群检出率(25～34岁、35～44岁、45～59岁)依次为13.2%、5.3%、8.3%。结论:HPV16、33和58型为该人群最常见的3种HPV高危型,高危型HPV感染机会在45～59岁组较高,低危型HPV感染机会在25～34岁组较高。
Objective: To understand the status of human papillomavirus (HPV) infection in urban and rural women in Yongkang city and the distribution of HPV infection in the population. Methods: From April 2007 to May 2008, a cluster stratified sampling method was used to screen cervical cancer in 10 communities in 10 towns in Yongkang City and 10 villages in the economic development zone. After signing the informed consent form, Epidemiological survey was conducted. At the same time, cervical exfoliated cells were collected and tested for cervical cytology in cervical exfoliated cells. HPV23 genotypes were detected by PCR in situ hybridization. Results: A total of 1 050 women were enrolled. The positive rate of high-risk HPV was 24.9% and the low-risk HPV was 9.2%. Among high-risk HPV-positive patients, the percentages of HPV types 16, 33 and 58 were 53.3%, 14.9% and 14.6%, respectively. The detection rate of high-risk HPV was 25-34, 35-44, 59 years old) were 28.5%, 20.0% and 30.6%, respectively. The detection rate of low-risk type HPV among the age group (25-34, 35-44, 45-59) was 13.2%, 5.3%, 8.3 %. CONCLUSION: HPV16, 33 and 58 are the most common types of high-risk HPV in the three groups. The chance of high-risk HPV infection is higher in the 45-59 age group. The chance of low-risk HPV infection is higher in the 25-34 age group.