论文部分内容阅读
目的探讨多药耐药基因(MDR1)C3435T多态性与儿童难治性癫癎耐药的关系。方法利用计算机在万方数据库、中国知网数据库、维普数据库和PubMed数据库中检索MDR1 C3435T多态性与儿童难治性癫癎耐药发生的文献,并应用RevMan 5.0软件对符合入选标准的文献进行异质性检验和效应值合并,同时进行敏感性分析和偏倚评估。结果纳入符合条件的相关文献5篇,共计难治性癫癎药物耐药组367例,药物敏感组488例。MDR1 CT、TT、CT+TT与儿童难治性癫癎耐药的合并OR值(95%CI)分别为0.89(0.65～1.23)、0.94(0.56～1.57)、0.92(0.64～1.32),Z=0.69、0.25、0.46,P=0.49、0.80、0.64。各研究的敏感性分析较稳定且无发表偏倚。结论 MDR1 C3435T多态性与儿童难治性癫癎耐药的发生无关。
Objective To investigate the relationship between multidrug resistance gene (MDR1) C3435T polymorphism and refractory epilepsy in children. Methods We searched the literature of MDR1 C3435T polymorphism and refractory epilepsy in children with Wanfang database, CNKI database, VIP database and PubMed database. RevMan 5.0 software was used to evaluate the compliance with inclusion criteria Heterogeneity tests and effect values are combined, along with sensitivity analysis and bias assessment. Results A total of 5 eligible articles were included. A total of 367 refractory epilepsy drug-resistant groups and 488 drug-sensitive groups were included. The combined odds ratio (95% CI) of MDR1 CT, TT, CT + TT and childhood refractory epilepsy were 0.89 (0.65-1.23), 0.94 (0.56-1.57) and 0.92 = 0.69, 0.25, 0.46, P = 0.49, 0.80, 0.64. Sensitivity analysis of each study is relatively stable and unpublished. Conclusion MDR1 C3435T polymorphism is not associated with the development of refractory epilepsy in children.