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尽管金属杀精作用发现很早,但直到Zipper等报导铜和锌具抗生育作用而又不致血铜升高才引起学者们的重视和兴趣。国外近几年来的研究开辟了一个颇具前景的抗生育领域。本文就金属抗生育研究进展,作用机制及其应用前景综述如下。古代医师在行医实践中发现金属具抗生育作用,Hippocrates即提出铜可能有杀精作用。1850年DequatrefaQe首次报导金属离子具杀精属性。一个多世纪后,White在研究水的重金属污染时分析了铜、锌等7种离子对人、公羊、牛和狗精子的毒性。目前许多学者对这些金属或其离子的杀
Although the metal spermicidal effect was found very early, it was not until the Zipper et al. Reported that copper and zinc had anti-fertility effects and did not cause blood copper to rise before attracting the attention and interest of scholars. Research abroad in recent years has opened up a promising anti-fertility field. This article on the metal anti-fertility research progress, mechanism and application prospects are summarized below. Ancient physicians in the practice of medicine found that metal with anti-fertility effects, Hippocrates that copper may have spermicidal effect. 1850 DequatrefaQe for the first time reported metal ions with spermicidal properties. More than a century later, White studied the toxic effects of seven ions of copper and zinc on human, ram, cow and dog sperm when studying heavy metal pollution of water. At present, many scholars kill these metals or their ions