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慢性肾功能衰竭(CRF)患者的血清维生素 A 浓度是增高的,然而,有关维生素 A 过多的可能毒性却了解很少。作者检查了一组 CRF 而作定期血液透析治疗病人的血清维生素 A 浓度与骨骼疾病的各种生化、放射学和组织学指标间的关系。38例患者平均年龄42.0±SD12.7岁,平均透析治疗时间55.4±43.5月患者均未曾作过甲状旁腺切除术和服用维生素 D 类或代谢物,但其中24例每日服用多种维生素制剂1～6片,每片含维生素 A2,500IU 和维生素 D_2 250IU。许多病人服用氢氧化铝制剂。测定全部患者血清维生素 A、钙、磷和硷性磷酸酶浓度,30例测血羟脯氨酸浓度,20例测免疫反应性甲状旁腺素浓度,透析36小时以上后抽取空腹血。28例正常对照
Serum vitamin A levels are elevated in patients with chronic renal failure (CRF), but little is known about the possible toxicity of vitamin A excess. The authors examined the relationship between serum vitamin A concentrations in patients undergoing regular hemodialysis for a group of CRFs and various biochemical, radiological, and histological features of skeletal disease. Thirty-eight patients had an average age of 42.0 ± SD of 12.7 years and an average of 55.4 ± 43.5 months of patients without parathyroidectomy and taking vitamin D or metabolites, but 24 of them took multiple daily vitamin supplements 1 to 6 tablets, each containing vitamin A 500 IU and vitamin D 2 250IU. Many patients take aluminum hydroxide preparations. Serum vitamin A, calcium, phosphorus and alkaline phosphatase concentrations were measured in all patients. Serum hydroxyproline concentrations were measured in 30 patients and immunoreactive parathyroid hormone concentrations in 20 patients. Fasting blood was drawn after dialysis for more than 36 hours. 28 cases of normal control