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目的了解系统性红斑狼疮(SLE)患者妊娠生育时病情变化及对胎儿的影响。方法对经我科治疗的14例SLE患者成功妊娠生育病例进行回顾分析。结果病情稳定、按计划妊娠的8例患者妊娠过程病情稳定,只有个别患者出现补体下降。未完全控制后、非有计划妊娠的患者妊娠过程较多出现病情活动需要增加激素用量,其中1例出现血小板减少,1例妊娠后确诊的轻症SLE患者也成功生育,但妊娠过程使用较大量激素。所生育新生儿只有1例有面部红斑和轻度转氨酶升高,其余未发现有与SLE及其治疗引起的相关异常。结论多数SLE患者在疾病控制后,可以安全地妊娠生育。育龄期女性SLE患者平时应做好避孕措施,有计划地进行妊娠生育,以防止妊娠对SLE病情的影响及有利于安全地生育健康的小孩。
Objective To understand the changes of the disease and its impact on the fetus during pregnancy in patients with systemic lupus erythematosus (SLE). Methods Retrospective analysis of successful pregnancy fertility cases in 14 SLE patients treated by our department. Results In stable condition, 8 patients under planned pregnancy were in stable condition during pregnancy, and only a few patients showed decreased complement. Incomplete control, non-planned pregnancy patients with more pregnancy activity need to increase the amount of hormonal activity, including 1 case of thrombocytopenia, 1 case of SLE patients diagnosed after pregnancy is also successful childbirth, but the pregnancy process using a larger amount hormone. Only one case of newborn infants with facial erythema and mild aminotransferase increased, and the rest did not find associated with SLE and its treatment-related abnormalities. Conclusions Most SLE patients can safely have a childbearing pregnancy after disease control. Women of childbearing age SLE patients should usually take good contraception, pregnancy and childbirth in a planned manner to prevent the impact of pregnancy on the condition of SLE and conducive to the safe birth of healthy children.