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目的：探讨ｐ５３蛋白表达与胃癌及癌前病变的相互关系。方法：用免疫组化染色法检测３３例肠化、２６例异型增生和２６例胃癌组织中ｐ５３蛋白的表达。结果：ｐ５３蛋白在胃癌组织中表达率最高（６１．５％），在异型增生和肠化组织中的表达率分别为３４．６％和１２．１％，组间有显著差异。各期胃癌组织中ｐ５３蛋白的表达无显著差异。结论：ｐ５３蛋白在胃癌前病变中已有阳性表达，在肠化、异型增生及胃癌组织中，其表达率依次增高；ｐ５３蛋白积累主要发生在癌前病变晚期及胃癌早期，其表达与胃癌发生密切相关。
Objective: To investigate the relationship between p53 protein expression and gastric cancer and precancerous lesions. Methods: Immunohistochemical staining was used to detect the expression of p53 protein in 33 cases of intestinal metaplasia, 26 cases of dysplasia and 26 cases of gastric carcinoma. Results: The highest expression rate of p53 protein was 61.5% in gastric cancer tissues, 34.6% and 12.1% in dysplasia and intestinal metaplasia tissues, respectively. There was a significant difference between the two groups. The expression of p53 protein in various stages of gastric cancer showed no significant difference. Conclusion: The expression of p53 protein in precancerous lesions of gastric cancer has been positive, and in the intestinal metaplasia, dysplasia and gastric cancer tissues, the expression of p53 protein increases in sequence. The accumulation of p53 protein mainly occurs in the advanced stage of precancerous lesions and in the early stage of gastric cancer, closely related.