论文部分内容阅读
现已确知,血清酸性蛋白酶活性来自两种免疫学上不同的天门冬氨酸蛋白酶,即胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ),其细胞来源略异.PGⅠ主要由胃底腺粘膜的主细胞合成,PGⅡ除由前述细胞合成外,还来源于胃窦的幽门腺.晚近的放免分析测定结果显示:胃、十二指肠溃疡患者血清PGⅠ、PGⅡ含量较正常升高,但胃溃疡(GU)患者血清PGⅠ/PGⅡ比值低于十二指肠溃疡(DU)患者.这一发现引起了人们的兴趣,因为PGⅠ/PGⅡ比值降低预示存在慢性胃炎.鉴于GU往往与胃炎伴存,作者推测:低PGⅠ/PGⅡ比
It is now known that serum acidic protease activity results from two immunologically distinct aspartic proteases, namely, pepsinogen I (PGI) and pepsinogen II (PGII), which have slightly different cellular origins, and PGI consists mainly of the stomach Glandular mucosa of the main cell synthesis, PG Ⅱ in addition to the aforementioned cell synthesis, but also from the antrum pyloric gland.Recently RIA analysis results showed: gastric, duodenal ulcer serum PG Ⅰ, PG Ⅱ levels were higher than normal , But the serum PGⅠ / PGⅡ ratio in patients with gastric ulcer (GU) is lower than that in patients with duodenal ulcer (DU) .This discovery has aroused people’s interest because the decrease of PGⅠ / PGⅡ ratio indicates the presence of chronic gastritis. With the coexistence, the authors speculate: low PG Ⅰ / PG Ⅱ ratio