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本文测定地甲肿患区饮食致大鼠甲状腺肿的代谢指标,实验前,部分大鼠注射30％碘化油0.2ml做对照组。4～7个月处死。实验结果表明,甲状腺碘浓度下降,MIT/DIT(MIT:一碘酪氨酸,DIT:二碘酪氨酸)、T_3/T_4(T_3:三碘甲腺原氨酸、T_4;甲状腺素)比值和TPO(甲状腺过氧化物酶)活性升高。这些代谢表现说明,实验组大鼠处于缺碘状态,并和人工低碘食致大鼠甲状腺肿的代谢表现一致。尽管甲状腺碘浓度下降,但组织总碘无明显变化,加上T_3/T_4比值和TPO活性增高,说明实验组大鼠对碘缺乏有一定的适应能力。
In this paper, to determine the metabolic index of rats with goiter caused by dietetic disease area, before the experiment, some rats were injected with 0.2% 30% iodized oil as the control group. 4 to 7 months executed. The experimental results showed that the thyroid iodine concentration decreased, the ratio of MIT / DIT (MIT: DIT: diiodotyrosine), T_3 / T_4 (T_3: triiodothyronine, T_4; thyroxine) And TPO (thyroid peroxidase) activity increased. These metabolic manifestations showed that rats in the experimental group were in an iodine deficient state and were consistent with the metabolic performance of the goiter in rats induced by artificial low iodine. In spite of the decrease of thyroid iodine concentration, there was no obvious change of total iodine in the tissue, and the ratio of T_3 / T_4 and the increase of TPO activity showed that the experimental rats had some adaptability to iodine deficiency.