论文部分内容阅读
目的:探讨临产前妊娠期糖尿病(GDM)患者中超敏C反应蛋白(hs-CRP)的含量及其与糖脂代谢可能存在的关系。方法:选择2006年7月～2007年7月在中国福利会国际和平妇幼保健院住院待产的GDM孕妇69例为研究组,正常孕妇100例为对照组,以免疫散射比浊法测定两组孕妇hs-CRP含量,及其与体块指数、空腹血糖、胆固醇、甘油三酯、尿酸及平均动脉压的关系。结果:GDM孕妇并发子痫前期时hs-CRP含量较正常孕妇显著增加(P<0.05);GDM患者hs-CRP含量与胆固醇、甘油三酯呈明显正相关(P<0.05)。妊娠期糖尿病孕妇巨大儿发生率、剖宫产率、住院时间均显著增高(P<0.05)。结论:hs-CRP增高与孕晚期GDM孕妇疾病进展有关,可作为GDM患者并发先兆子痫的预测指标。
Objective: To investigate the content of hs-CRP in prenatal gestational diabetes mellitus (GDM) and its relationship with the possible metabolism of glucose and lipid. Methods: From July 2006 to July 2007, 69 pregnant women with GDM in Chinese Welfare Institute International Peace Maternity and Child Health Hospital were selected as the study group and 100 normal pregnant women as the control group. The immunostaining nephelometry hs-CRP content, and its relationship with body mass index, fasting blood glucose, cholesterol, triglycerides, uric acid and mean arterial pressure. Results: The content of hs-CRP in pregnant women with GDM complicated with preeclampsia was significantly higher than that in normal pregnant women (P <0.05). The content of hs-CRP in GDM patients was positively correlated with cholesterol and triglyceride (P <0.05). The incidence of macrosomia, cesarean section rate and hospital stay in pregnant women with gestational diabetes mellitus were significantly increased (P <0.05). Conclusion: The increase of hs-CRP is associated with the progress of GDM pregnant women in the third trimester of pregnancy, which can be used as a predictor of preeclampsia in GDM patients.