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Castleberry 等(1981)对4例非何杰金病儿童和2例急性淋巴细胞白血病采用 LSA_2-L_2方案(Ara-c100mg/M~2/d,连用5天,休息2天后继以6TG50mg/M~2/d,连用4周)进行治疗。在 Ara-c 用后6～12小时内,患者突然发热39～40℃、肌肉酸痛、骨痛,同时有胸痛、皮疹、结膜炎、畏光等副作用。当时并无感染,停 Ara-c24小时内症状消退,作者将上述症状称为 Ara-c 综合征。在出现症状前,患儿在13.5个月中平均 Ara-c 总量达3200(2298～5387)mg/M~2。引起本综合征的病因,可能是对 Ara-
Castleberry et al. (1981) treated 4 children with non-Hodgkin’s disease and 2 with acute lymphoblastic leukemia using the LSA 2-L 2 regimen (Ara-c 100 mg / M ~ 2 / d for 5 days, 2 / d, once every 4 weeks) for treatment. Within 6 to 12 hours after Ara-c use, the patient suddenly has fever of 39-40 ° C, muscle aches and pains, and has side effects such as chest pain, skin rashes, conjunctivitis and photophobia. At that time there was no infection, stop Ara-c 24 hours the symptoms subsided, the author of the above symptoms is called Ara-c syndrome. Before the onset of symptoms, the mean Ara-c volume in the 13.5 months was 3200 (2298-5387) mg / M ~ 2. Cause of the etiology of this syndrome may be Ara-