论文部分内容阅读
目的:检测过氧化物酶体增殖物激活受体-γ(PPAR-γ)和环氧合酶-2(COX-2)在乳腺导管内癌和浸润性导管癌中表达情况,探讨PPAR-γ和COX-2表达关系。方法:应用免疫组化SP法检测乳腺导管内癌和浸润性导管癌组织中PPAR-γ和COX-2表达,并对两者与临床特征的相关性进行χ2检验和Spearman等级相关分析。结果:与乳腺导管内癌相比,乳腺浸润性导管癌中PPAR-γ阳性率降低,而COX-2表达增加(P<0.05)。在乳腺导管内癌和浸润性导管癌中PPAR-γ与COX-2均呈负相关关系。浸润性导管癌中PPAR-γ和COX-2与组织学分级、临床分期、淋巴结转移和复发均有关系(P<0.05)。结论:乳腺导管癌中PPAR-γ与COX-2表达呈负相关关系,两者与肿瘤的进展和预后密切相关。
Objective: To detect the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and cyclooxygenase-2 (COX-2) in ductal carcinoma of the breast and invasive ductal carcinoma, And COX-2 expression. Methods: Immunohistochemical SP method was used to detect the expression of PPAR-γ and COX-2 in breast ductal carcinoma and invasive ductal carcinoma. The correlation between them was analyzed by Chi-square test and Spearman rank correlation analysis. Results: Compared with the intraductal carcinoma, the positive rate of PPAR-γ in invasive ductal carcinoma of the breast was decreased and the expression of COX-2 was increased (P <0.05). There was a negative correlation between PPAR-γ and COX-2 in ductal carcinoma of the breast and invasive ductal carcinoma. PPAR-γ and COX-2 in invasive ductal carcinoma were correlated with histological grade, clinical stage, lymph node metastasis and recurrence (P <0.05). Conclusion: There is a negative correlation between the expression of PPAR-γ and COX-2 in breast ductal carcinoma, both of which are closely related to tumor progression and prognosis.