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目的探讨枸橼酸抗凝在脑卒中高危尿毒症患者血液透析(HD)中的应用效果。方法选取2003年10月—2013年10月安阳市人民医院收治的行HD脑卒中高危尿毒症患者40例,按抗凝方案不同分为观察组与对照组,各20例。观察两组患者滤器凝血情况、肾功能指标(血肌酐、尿素氮、尿酸)及不良反应发生情况。结果观察组患者滤器凝血情况优于对照组,差异有统计学意义(P<0.05);观察组患者血肌酐、尿素氮、尿酸水平低于对照组,差异有统计学意义(P<0.05);观察组患者脑血管意外发生率低于对照组,差异有统计学意义(P<0.05)。结论枸橼酸抗凝在脑卒中高危尿毒症患者HD中的应用效果显著,可改善滤器凝血情况,提高患者肾功能,且不良反应小。
Objective To investigate the effect of citrate anticoagulation in hemodialysis (HD) patients with high risk of stroke and stroke. Methods From October 2003 to October 2013, Anyang People’s Hospital of 40 cases with high risk of uremia in HD stroke were divided into observation group and control group according to different anticoagulation regimen, 20 cases in each group. Coagulation of the two groups of patients with coagulation, renal function indicators (serum creatinine, urea nitrogen, uric acid) and adverse reactions were observed. Results The coagulation of filter in observation group was better than that in control group (P <0.05). The serum creatinine, urea nitrogen and uric acid in observation group were lower than those in control group (P <0.05). The incidence of cerebrovascular accident in the observation group was lower than that in the control group, with significant difference (P <0.05). Conclusion Citrate anticoagulation is effective in treating HD in stroke patients with high risk of uremia, which can improve the coagulation of the filter and improve the renal function in patients with small adverse reactions.