Increasing the dosage of vincristine： a clinical and pharmacokinetic study of continuous-infusion vi

• 作 者: KellieSJ KoopmansP EarlJ NathC
• 机 构: OncologyUnit
• 出 处: 中国神经肿瘤杂志
• 发表日期: 2004年2期
• 关键词: 长春新碱 剂量增加 小儿 中枢神经系统淋巴瘤 化疗

<正> BACKGROUND: Vincristine (VCR) is widely used to treat patients with malignant disease; among the patients treated with VCR are children with brain tumors. In vitro studies have demonstrated that the cytotoxic activity of VCR is related to both e