Loss of DPC4 expression and its correlation with clinicopathologica parameters in pancreatic carcino

• 作 者: ZhanHua Yuan-ChunZhang] Xiao-M
• 机 构: PekingUnionMedicalCollege,DepartmentofGeneralSurgery,DepartmentofImmunology
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2003年12期
• 关键词: 胰腺癌 临床病理学 表达缺失 DPC4基因 抑癌基因

AIM: DPC4 is a tumor suppressor gene on chromosome 18q21.1 that has high mutant frequencies in pancreatic carcinogenesis. The purpose of this study was to investigate the role of DPC4 alterations in tumorigenesis and progression of pancreatic carcinomas.