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类胰岛素生长因子(IGFs)是调节生长激素对软骨细胞代谢和骨骼生长作用的多肽激素。IGFs 与一至更多的载体蛋白结合在血液中运行。肾病综合征(NS)是以肾小球对血浆蛋白通透性增加为特征,大部分 IGFs 与载体蛋白结合,载体蛋白从尿中的丢失,导致血浆 IGFs 降低,故引起长期患 NS 的病儿生长迟缓。本文的目的是测定活动性 NS 病儿的血清 IGF-1和 IGF-2的浓度和判断其尿中是否含载体蛋白。病例和方法本文对25例活动性 NS 病儿和20例年龄和性别与研究组一致的儿童作为对照组进行了研究。其中微小病变型17例,局限节段性肾小球硬化症5例,膜性增生型肾小球肾炎3例。男19例,女6例。年龄3～18岁,平均10岁。所有患儿均患活动性 NS,有大量蛋白尿和低蛋白血症。在研究前至少一个月均未接受糖皮质激素治
Insulin-like growth factors (IGFs) are polypeptide hormones that regulate the effects of growth hormones on chondrocyte metabolism and bone growth. IGFs bind to one or more carrier proteins and run in the bloodstream. Nephrotic syndrome (NS) is characterized by an increase in glomerular permeability to plasma proteins. Most IGFs bind to carrier proteins and loss of carrier proteins from the urine results in a reduction of plasma IGFs and hence a long-term illness in children with NS Slow growth. The purpose of this paper is to determine the concentration of serum IGF-1 and IGF-2 in children with active NS disease and to determine if they contain a carrier protein in their urine. Cases and Methods In this study, 25 children with active NS disease and 20 children aged and sex matched the study group were enrolled as controls. Among them, 17 cases were minimal lesion, 5 cases were localized segmental glomerulosclerosis and 3 cases were membranous proliferative glomerulonephritis. 19 males and 6 females. Age 3 to 18 years old, average 10 years old. All children with active NS, a large number of proteinuria and hypoproteinemia. No glucocorticoids were administered at least one month before the study