【摘 要】
：
Objective: To analyze the aberrant methylation of p16 gene and DAPK gene in sera from primary liver cancer patients ad to evaluate the clinical significance. Me
【机 构】
：
Department of Medical Oncology,Laboratory of Clinical Immunology
论文部分内容阅读
Objective: To analyze the aberrant methylation of p16 gene and DAPK gene in sera from primary liver cancer patients ad to evaluate the clinical significance. Methods: A methylation-specific PCR was performed for the detection of promoter hypermethylation of p16 gene and DAPK gene in blood DNA from 64 cases of HCC patients, and to analyze the relation of the aberrant methylation of p16 gene and KAPK gene and the clinical pathological data. Results: 76.6%(49/64) of the sera from 64 cases of HCC patients showed hypermethylation for p16 promoter and 40.6% (26/64) for KAPK promoter, whereas no methylated p16 gene promoter and DAPK gene promoter were found in sera from benign liver diseases patients and normal control. Methylated p16 gene and KAPK gene promoters in sera did not strongly correlated with HBsAg, stage,metastasis and differentiation in HCC; but strongly correlated with AFP. Conclusion: Detection of the aberrant methylation of p16 gene and KAPK gene in blood DNA from HCC patients might offer an effective means for the earlier auxiliary diagnosis of the malignancy.
其他文献
智能物流就是在现代物流的基础上,综合运用物联网技术,计算机技术,自动控制技术和智能决策技术等实现的物流智能化.智能物流的特征是能够独立完成订单、运输、仓储和配送等物
近年来,天津市银行卡业务呈现快速发展趋势,但与此同时,银行卡业务发展中存在的问题也不容忽视,各类风险日渐突出.本文通过对天津市银行卡市场的调查,对辖内银行卡的风险状况
本文通过了解乌兰察布市金融消费者权益保护工作实际情况,发现存在的突出问题和主要障碍,并提出相应的解决措施,以期建立切实可行的金融消费者权益保护工作机制.
Hemangiopericytoma is a rare tumor especially when it rises in the peritoneal cavity. We present a case of a 60-year-old woman with an isolated recurrent hemang
DNA methylation is the most intensively studied epigenetic phenomenon, disturbances of which result in changes in gene transcription, thus exerting drastic impa
两晋时期,随着士族门阀在政治、经济领域特权的确立,教育上也逐渐有了享受特权的渴望.在这样的历史背景下,两晋教育呈现出有异干两汉、三国的明显特征,不仅出现了为适应门阀
AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-contro
Hepatoblastoma is the most common primary hepatic tumor of children. However, only a very few cases have been reported in adults. Most studies support treatment
Background In vivo proton magnetic resonance spectroscopy (MRS) provides a noninvasive method of examining a wide variety of cerebral metabolites in both health
Objective: To investigate the differentiation-inducing effects of all-trans-retinoic (ATRA) to HPV16 subgenesimmortalized human endocervical cells (H8 cell) in