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目的:探讨静脉滴注氨溴索佐治毛细支气管炎的疗效及安全性。方法:以2006年1～12月住院的126例毛细支气管炎患儿为对照组,2007年1～12月住院的124例毛细支气管炎患儿为治疗组,两组均给予常规抗感染、激素、解痉、止咳等治疗,必要时吸痰。重症患儿吸氧、给予血管活性药物;有心衰时给予西地兰、速尿对症处理,治疗组在上述基础上静脉滴注盐酸氨溴索,2mg·kg-1·次-1,2次/d,疗程5～7天。比较两组症状、体征消失的时间,住院时间并观察治疗组的不良反应。结果:治疗组在改善喘憋症状,消除肺部哮鸣音、痰鸣音,缩短住院时间,显效率等方面均优于对照组。结论:静脉滴注氨溴索佐治毛细支气管炎疗效满意,未发现明显的不良反应,值得临床推广使用。
Objective: To investigate the curative effect and safety of intravenous infusion of ambroxol on bronchiolitis. Methods: A total of 126 children with bronchiolitis who were hospitalized from January to December 2006 were selected as the control group. 124 children with bronchiolitis admitted to hospital from January to December 2007 were treated. The two groups were given routine anti-infective, hormone , Antispasmodic, cough and other treatment, if necessary, suctioning. Severe infants with oxygen, giving vasoactive drugs; have cedilanid given heart failure, furosemide symptomatic treatment, the treatment group on the basis of intravenous infusion of ambroxol hydrochloride, 2mg · kg-1 · times -1,2 Times / d, treatment of 5 to 7 days. The symptoms, signs disappeared, hospital stay and adverse reactions in the treatment group were compared. Results: The treatment group was superior to the control group in improving the symptom of wheezing, eliminating the wheeze and phonation of the lung, shortening the length of hospital stay, and obviously improving the efficiency. Conclusion: The results of intravenous infusion of ambroxol bronchitis were satisfactory, no obvious adverse reactions were found and it is worth to be used clinically.